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Configure email security gateway

Hi folks,

I need some help regarding mail security configuration,

I am configuring the inbound destination and outbound gateway, 

The costumer have two types of mailboxes, Exchange and Office365,

How can I configure and make it works for two of that mentioned above?

Another thing, 

1- is the ISP or internal server address?

2 - is the ISP or internal server address?

Thank you

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