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Email Delivery Pending /Failures

Hello All,

We are having issues with mail delivery today. Looking at the logs in Exchange I am seeing the following entries. Anyone else having issue? 

Reason: [{LED=450 4.4.317 Cannot connect to remote server [Message=451 4.4.0 Socket error SocketError] [] [LastAttemptedIP=] []};{MSG=451 4.4.0 Socket error SocketError};{ OutboundProxyTargetIP: OutboundProxyTargetHostName:

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