Blocking Email where From and Reply-To are different

Pretty much what the subject says, we've been getting spam and phishing emails making it through the Gateway where the From and Reply-To addresses are different. For example the "From" will be "ReasonableName@CompanyWeTrust.com" and the Reply-To will be "TotalPhish@email.ru". Is there any way to flag, quarantine, or block these types of emails?