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Event 1050, mail stuck in queues because of PureMessage. Scan very slow

Our Exchange 2010 SP3 queues keep building up with the event below.

When we disable the transport scan, mail flows again.

Also much delays in On-access (database) scan, so reading mail cause complaining users.

Removing or disabling PureMessage resolves this problem.

Any suggestions?

Sophos Support does not have an answer...

Event 1050 event:

The execution time of agent 'PmE12Transport' exceeded 90000 milliseconds while handling event 'OnRoutedMessage' for message with InternetMessageId: 'Not Available'. This is an unusual amount of time for an agent to process a single event. However, Transport will continue processing this message.

:45689


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