mass shutdown of tamper protection and subsequent uninstallation of a group of users

The only real way to do this is turn it off in the general settings - but that disables for everyone. For specific devices - you can turn Tamper Protection off in the device page - one by one. Tamper Protection was specifically made to be difficult to turn off - to prevent unintentional exposure and risk of the endpoints. 

how can we monitor in geenral; How many systems have TP OFF>?
We have many admins and 12K Clients and few admins disable and forget to enable; How do we trace?
P.S-already placed a feature request few yrs ago

Hi, I think you can use Live Discover to search in the registry by selecting Registry category:

And then select de Query "Display registry section" like show below:

And then in the fields marked below:

You will enter:

HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Sophos Endpoint Defense\TamperProtection\Config\SEDEnabled

And run the query to the endpoints you want to. That Query will send you data back about the value of this registry (tamper protection enable or no)

And finally, you will get this response:

If valueData is:
1 enable
2 disable

Then you can export that to csv

Many thanks Juan for your kind  response. since we have 13K clients cannot query them all.But we managed to query via 
https://developer.sophos.com/docs/endpoint-v1/1/routes/endpoints/%7BendpointId%7D/tamper-protection/get
We have this info on our log server and we built a dashboard this evening for this 

Many thanks Juan for your kind  response. since we have 13K clients cannot query them all.But we managed to query via 
https://developer.sophos.com/docs/endpoint-v1/1/routes/endpoints/%7BendpointId%7D/tamper-protection/get
We have this info on our log server and we built a dashboard this evening for this 

Great!!