System.IO.IOException: Pipe is broken

Starting Dec 21st we started seeing a tremendous amount of errors on both our Server Infrastructure and Endpoint devices.  This created issues with certain .NET related applications on end users workstations that required restarting various applications. One application particularly troublesome was Mimecast For Outlook. Upon investigating we found that the only resolution to fix these errors was to completely remove Sophos (obviously that's not a solution nor a risk we're willing to take). 

Sample Errors - 

28-12-2020 09:07:41,964 ERROR [12] HOST: Domain Unhandled Exception: System.IO.IOException: The pipe is being closed.

   at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
   at System.IO.Pipes.NamedPipeServerStream.BeginWaitForConnection(AsyncCallback callback, Object state)
   at System.IO.Pipes.NamedPipeServerStream.WaitForConnection()
   at Mimecast.Mapi.Remote.NamedPipesServer.AcceptPipeConnection(IAsyncResult asyncResult)
   at System.IO.Pipes.NamedPipeServerStream.AsyncWaitForConnectionCallback(UInt32 errorCode, UInt32 numBytes, NativeOverlapped* pOverlapped)
   at System.Threading._IOCompletionCallback.PerformIOCompletionCallback(UInt32 errorCode, UInt32 numBytes, NativeOverlapped* pOVERLAP). IsTerminating: True (Program)

Message=Application: msddsk.exe
Framework Version: v4.0.30319
Description: The process was terminated due to an unhandled exception.
Exception Info: System.IO.IOException
   at System.IO.__Error.WinIOError(Int32, System.String)
   at System.IO.Pipes.PipeStream.WinIOError(Int32)
   at System.IO.Pipes.NamedPipeServerStream.GetImpersonationUserName()
   at Mimecast.Mapi.Remote.NamedPipesServer.AcceptPipeConnection(System.IAsyncResult)
   at System.IO.Pipes.NamedPipeServerStream.AsyncWaitForConnectionCallback(UInt32, UInt32, System.Threading.NativeOverlapped*)
   at System.Threading._IOCompletionCallback.PerformIOCompletionCallback(UInt32, UInt32, System.Threading.NativeOverlapped*)

Is anyone else seeing this? We'll certainly open a Ticket with support but wanted to also understand the scope. 

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