Hello, it depends a little on what other roles the machine performs and how you install Sophos.
If you have a remote SQL server, that would lighten the load on the Sophos management server as you could use that to host the database. This would save a SQL process and the associated memory and disk I/O that goes with that.
If you have a file server you could write the distribution points to that, such that the clients updating wouldn't load the server. Again saving disk I/O and network resources.
