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Relay not permitted DROP in ACL

hi altogether, 

I have a problem which I am trying to solve all day long now. I have setup SMTP Protection and outbound it works perfectly - inbound no chance to make it running - I always receive this error message:

2021:06:16-16:45:18 core exim-in[5643]: 2021-06-16 16:45:18 SMTP connection from [178.x.x.x]:55240 (TCP/IP connection count = 1)

2021:06:16-16:45:18 core exim-in[30965]: 2021-06-16 16:45:18 H=mail.x.x [178.x.x.x]:55240 X=TLS1.2:ECDHE-RSA-AES256-GCM-SHA384:256 CV=no F=<a.b@c.d rejected RCPT <administrator@d.f>: Relay not permitted
2021:06:16-16:45:18 core exim-in[30965]: 2021-06-16 16:45:18 SMTP connection from mail.x.x [178.x.x.x]:55240 closed by DROP in ACL
when I implement a NAT rule which sends the traffic directly to Exchange, everything works - so the error has to be on the Sophos UTM. I have tried multiple settings in the relay tab with no result. Right now I only have the internal ip of the Exchange with rdns on the official DNS at the Host Based Relay Tab under Allowed / Hosts Network. 
Does anyone has an idea what the reason for this could be?

Thank you very much in advance, 
best regards, 


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