smtpd daemon not running after email address change

At a bit of a loss here.  Made a simple change to the admin's email address, and it appears that our daemon is messed.  IT is not critical, but none of our notifications are being sent out any more.

SMTP log:

2020:07:24-11:56:18 Claimsbridge-1 smtpd[31851]: MASTER[31851]: (Re-)loading configuration from Confd
2020:07:24-11:56:18 Claimsbridge-1 smtpd[31851]: MASTER[31851]: QR globally disabled, status one set to 'disabled'
2020:07:24-11:56:18 Claimsbridge-1 smtpd[31851]: MASTER[31851]: QR globally disabled, status two set to 'disabled'
2020:07:24-11:56:18 Claimsbridge-1 exim-in[31860]: 2020-07-24 11:56:18 exim 4.82_1-5b7a7c0-XX daemon started: pid=31860, no queue runs, listening for SMTP on port 25 (IPv4) port 587 (IPv4) and for SMTPS on port 465 (IPv4)
2020:07:24-11:56:44 Claimsbridge-1 smtpd[31856]: QMGR[31856]: Permanent database error detected, exiting.
2020:07:24-11:56:45 Claimsbridge-1 smtpd[31851]: MASTER[31851]: Queue manager died, shutting down.
2020:07:24-11:56:45 Claimsbridge-1 smtpd[31851]: MASTER[31851]: Termination requested, sending SIGTERM to child processes
2020:07:24-11:56:45 Claimsbridge-1 smtpd[31851]: MASTER[31851]: Exiting

I have tried killing and restarting the process.  No luck.

Admin notification log (this one should be simply for a login):

2020:07:24-12:37:41 Claimsbridge-2 postfix/qmgr[1573]: 787662266D: from=<do-not-reply@fw-notify.net>, size=893, nrcpt=1 (queue active)
2020:07:24-12:37:41 Claimsbridge-2 postfix/smtp[5690]: connect to localhost[127.0.0.1]:25: Connection refused
2020:07:24-12:37:41 Claimsbridge-2 postfix/smtp[5690]: 787662266D: to=<xxxx@claimsbridge.com>, relay=none, delay=0.16, delays=0.09/0.08/0/0, dsn=4.4.1, status=deferred (connect to localhost[127.0.0.1]:25: Connection refused)

any thoughts or help?  Can't roll back to an old backup since we made too many changes since...and I would have difficulty putting them all back in place.  

Jason