Let's Encrypt Certificate Generation Failed

I'm trying to set up lets encrypt certificates for my user portal for the first time and am getting an error when trying to create them. This is the log (actual domains/IPs replaced with placeholders):

2019:12:20-09:33:02 remote letsencrypt[465]: I Renew certificate: handling CSR REF_CaCsrRemote for domain set [remote.domain.com]
2019:12:20-09:33:02 remote letsencrypt[465]: I Renew certificate: running command: /var/storage/chroot-reverseproxy/usr/dehydrated/bin/dehydrated -x -f /var/storage/chroot-reverseproxy/usr/dehydrated/conf/config -c --accept-terms --domain remote.domain.com
2019:12:20-09:33:21 remote letsencrypt[465]: I Renew certificate: command completed with exit code 256
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: ERROR: Challenge is invalid! (returned: invalid) (result: {
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "type": "http-01",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "status": "invalid",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "error": {
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "type": "urn:ietf:params:acme:error:connection",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "detail": "Fetching remote.domain.com/.../ipM_zY4XPqCtV8KPSAPmOrX61DQ2MYSvvHDutyc0ubQ: Timeout during connect (likely firewall problem)",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "status": 400
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: },
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "url": "acme-v02.api.letsencrypt.org/.../nLm_kg",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "token": "ipM_zY4XPqCtV8KPSAPmOrX61DQ2MYSvvHDutyc0ubQ",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "validationRecord": [
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: {
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "url": "remote.domain.com/.../ipM_zY4XPqCtV8KPSAPmOrX61DQ2MYSvvHDutyc0ubQ",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "hostname": "remote.domain.com",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "port": "80",
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "addressesResolved": [
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "111.111.111.111"
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: ],
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: "addressUsed": "111.111.111.111"
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: }
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: ]
2019:12:20-09:33:21 remote letsencrypt[465]: E Renew certificate: COMMAND_FAILED: })
2019:12:20-09:33:22 remote letsencrypt[465]: I Renew certificate: sending notification WARN-603
2019:12:20-09:33:22 remote letsencrypt[465]: [WARN-603] Let's Encrypt certificate renewal failed accessing Let's Encrypt service
2019:12:20-09:33:22 remote letsencrypt[465]: I Renew certificate: execution completed (CSRs renewed: 0, failed: 1)

Can anyone help with this?