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VMware VMotion enables the live migration of running virtual machines from one physical server to another transparently with zero downtime. This KB article explains the complications that arise from VMotion and why some products are not supported.
Sophos for Virtual EnvironmentsWhen installing Sophos for Virtual Environments Distributed Resource Scheduler (DRS) should be turned off. This stops the Security VM moving straight away and losing connectivity. VMotion can be turned back on after installation.
Also see:Sophos for Virtual Environments - Security Virtual Machine Installation Fails