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The client runs fine in sandboxie however when the actual game opens i receive an error. I believe this wasn't always the case and you could run league of legends before, but now you can't.
Please see the original post and provide the required info as per my response there.
League or Legends is not a supported app, but with more info, other users may be able to further assist:Is it possible to run league of legends in sandboxie?
Closing this thread as dupe.