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I'm trying to find documentation about the network isolation of applications ran in the sandbox. Specifically, I'm trying to quell concerns that some malware/worm couldn't touch the sandbox host machine, but it could spread to neighboring computers on the network. I've googled for it, but to no avail.
In case anyone else comes here looking for this info, I think I have found what I was looking for here: https://www.sandboxie.com/SandboxHierarchy
"Files that are created or modified on a remote network share are redirected into the sandboxed share\\servername\\sharename folder."
That answers my question about how Sandboxie handles an attempt by the malware to modify files on a remote system: