Issue with Creative Cloud apps unable to overwrite files on the server.

Thanks for reaching out to the Sophos Community Forum.

May I ask what version of Sophos is installed on the affected system while this issue is present?

The reference id you provided corresponds to an issue resolved in version 10.3.4, so the issue you are experiencing may be something new, though this could be related to the same underlying behaviour. 

Hi Kushal,

We are running version 10.3.7

Regards

Bob

Thanks for clarifying. 

I  was able to locate the following article which may apply to the issue you're experiencing. 
- Sophos Mac Endpoint: Files may become locked on SMB network volumes

Let me know if this is the case with your environment.

Hi Kushal,

The article was interesting but we are accessing the shares via afp rather than smb.

Regards

Bob

Hi Kushal,

Is it possible to have a phone call about this to try and come up with a solution as it is effecting our whole business and is compromising how all our Mac users work?

Regards

Bob

You can reach our support team using the regional phone numbers available under "For Critical Cases" on the following page or by opening a case with our team from the support portal. 
- support.sophos.com
- Support Portal

The assistance I can provide personally is limited to our forums. 

Let me know if disabling any specific protection features from the Local policy override, as described in the following article, resolves the issue.
- https://support.sophos.com/support/s/article/KB-000036572?language=en_US

The following features from Sophos Central may be more likely to result in the symptoms you're experiencing. For testing purposes, I suggest creating a new Threat Protection policy from Sophos Central and to apply the policy to one test device. 

Real-time Scanning - Local Files and Network Shares:
 - Remote files

Runtime Protection:
 - Protect from remotely run ransomware

I don't suggest leaving these turned off for an extended period, but as a temporary work-around, this may work.