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Windows 2020 H2 - Sophos Antivirus service fails and puts computer into self isolation

Just raised case with sophos support - running sophos core agent 2.10.7 beta, endpoint advanced beta and sophos Intercept x 2.0.18 Beta.  

Ran windows update for 2020 H2 and sophos put device into self isolate as Antivirus service cannot run (just says starting and error -2147467259

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