Just raised case with sophos support - running sophos core agent 2.10.7 beta, endpoint advanced 10.8.9.1 beta and sophos Intercept x 2.0.18 Beta.
Ran windows update for 2020 H2 and sophos put device into self isolate as Antivirus service cannot run (just says starting and error -2147467259
Hi lawrence Young
How many machines are facing this issue? Check out the steps listed in this article and see if it helps to fix the issue.